CreGAAtine® is a unique combination of creatine monohydrate and its precursor, GAA. This blend has been shown to boost creatine levels in the muscle while also efficiently crossing the blood brain barrier for enhanced cognitive function. For best results, consumption of CreGAAtine® both pre-workout and post workout is recommended.
BUILD MUSCLE*
INCREASE STRENGTH*
ENHANCE RECOVERY*
CreGAAtine® is a new and innovative ingredient combining creatine monohydrate and guanidinoacetic acid (GAA). We can break this ingredient down into two separate parts and summarize how the combination of these two compounds works together to produce desired results.
Sometimes called the “grandfather” of dietary supplements, creatine is, along with caffeine, one of the most extensively studied dietary compounds. Certainly, it is the most well-studied ergogenic aid. The extensive amount of data on creatine demonstrates that it positively contributes to dilation of the vasculature, plasma-nutrient mobilization, post-workout nitrogen retention and protein synthesis, along with dose-dependently increasing contractile force through ATP (adenosine triphosphate) provision (i.e., it helps support increased strength).
A less commonly known substance, GAA, has been a part of human nutrition since the 1950s. It is a natural organic compound known for its utilization in creatine biosynthesis but has also demonstrated beneficial energy-boosting effects in various studies. It has also been suggested to trigger several creatine-independent mechanisms that can provide benefits for the human body. Besides being a direct precursor to creatine, GAA can also reduce blood glucose concentration, spare arginine to be used for muscle protein synthesis, modulate taste, and perhaps alter methylation and fat deposition in organs such as the liver.
Now that we know a little bit about the two components of CreGAAtine®, what makes their combination so special? This blend shows a vastly superior effect when compared against creatine, or its other various forms. CreGAAtine® can boost muscle and brain energetics with superior creatine increasing effects. In studies, CreGAAtine® was shown to boost creatine concentration in the skeletal muscle but up to 16.9% over the course of 4 weeks. Creatine supplementation alone equated to roughly 2% increase. So, we are looking at over an 800% increase in skeletal muscle creatine concentration with CreGAAtine® supplementation. CreGAAtine® is also able to cross the blood brain barrier much more intact than traditional creatine on its own. CreGAAtine® has been shown to increase creatine levels in the brain by up 3.9x in grey matter and 1.9x higher in white matter. Additionally, CreGAAtine® binds to multiple receptors to allow for up to 4 ways to enter the cell, versus the 1 way that creatine alone can. This may not sound negative, but with only one way to enter the cell, this can lead to an oversaturation over continual use which can result in a lower capacity to transport creatine into the cell. Basically, there is a backlog which prevents an adequate supply of creatine to its targets. There are also no known side effects of CreGAAtine®, meaning no bloating, water retention, GI distress, etc.
